Gene Variant May Boost Risk for Late-Life Depression

A  new study has found that a gene variant, thought to be carried by nearly 25 percent of the population, increases the odds of developing late-life depression.

People with apolipoprotein-E4, called ApoE4 for short, have a 20 percent greater chance of developing clinically significant depressive symptoms later in life compared to those who don’t have the gene variant, said Rosanna Scott, lead author of the study.

A Ph.D. candidate in clinical psychology at the University of Central Florida, Scott found the link while working on her thesis.

“Some genes are deterministic, like the one that causes Huntington’s disease where if you’ve got it, you’ll get the disease. This isn’t one of those genes,” said Dr. Daniel Paulson, Scott’s faculty advisor and an assistant professor of psychology who co-authored the study.

Scott used health and well-being data of 3,203 participants as they aged from 53 to 71 years old. The data came from the Wisconsin Longitudinal Study, a long-term study of health, relationships, mortality, and more of people who graduated from Wisconsin high schools in 1957.

According to the data, those who have ApoE4 reported more symptoms of depression as they aged.

“Her thesis addressed a critical gap in the theoretical framework of this area of study,” Paulson said. “Now we can more systematically move forward with research on causes and treatments for late-life depression.”

Scott wanted to study ApoE4 and its potential links to depression because this variant of the ApoE gene is also known to negatively impact how a body handles cholesterol.

Previous research, which Scott confirmed in the first paper of her thesis published in the International Journal of Geriatric Psychiatry, found that vascular-system risk factors, such as high cholesterol, hypertension and high blood sugar, also increase risk for depression.

Vascular burden impacts how blood and nutrients are delivered throughout the body and to the brain, impacting mood. Scott wondered if adults with ApoE4 and high vascular burden are at a compounded risk for depression.

Her research concluded that ApoE4 and poor vascular health do not create a compounded risk, but both independently increase the likelihood of depression.

Scott said her findings add clarity to the literature that’s already out in the scientific community on this topic. Prior research findings were inconsistent regarding ApoE4 and its risks for depression, and were done with small sample groups, too young a sample, or with data that wasn’t collected during a long period of time, she said.

“Bottom line, you do statistically have a higher risk of developing depression if you have ApoE4, but it’s not deterministic. You can’t change your genes, but you do have some control over improving your health,” she said. “That should be encouraging.”

The study was published in The Journal of Clinical Psychiatry.

Source: The University of Central Florida

Photo: Rosanna Scott, left and Daniel Paulson, right take a look at depression and a gene variant. Credit: University of Central Florida.

Posted by Patricia Adams