Mouse Study: Muscles May Impact Sleep Disorders

A new study shows that a protein in muscle can lessen the effects of sleep loss in mice.

The finding — a collaboration between University of Texas (UT) Southwestern’s Peter O’Donnell Jr. Brain Institute and two other medical centers — gives scientists a new target besides the brain to develop therapies for people with excessive sleepiness.

“This finding is completely unexpected and changes the ways we think sleep is controlled,” said Dr. Joseph S. Takahashi, chairman of Neuroscience at UT Southwestern Medical Center.

The research demonstrates how a circadian clock protein in the muscle — BMAL1 — regulates the length and manner of sleep.

Study findings appear in the journal eLife.

While the protein’s presence or absence in the brain had little effect on sleep recovery, mice with higher levels of BMAL1 in their muscles recovered from sleep deprivation more quickly.

In addition, removing BMAL1 from the muscle severely disrupted normal sleep, leading to an increased need for sleep, deeper sleep, and a reduced ability to recover.

Takahashi said the finding may eventually lead to therapies that could benefit people in occupations requiring long stretches of wakefulness, from military to airline piloting.

“These studies show that factors in muscles can signal to the brain to influence sleep. If similar pathways exist in people, this would provide new drug targets for the treatment of sleep disorders,” said Takahashi.

The collaborative study is viewed as major step toward understanding the mysteries of sleep.

Source: UT Southwestern

Posted by Patricia Adams